Effect of paracetamol on pharmacokinetics of isoniazid in Teddy goats

In this study the effect of paracetamol on pharmacokinetics [PK] of isoniazid [INH] in Teddy goats was investigated. INH was administered as a single oral dose at 10 mg/kg body weight to every experimental goat. After a wash out period of 7 days, INH and paracetamol [at the rate of 15 mg/kg body weight] were given simultaneously through oral route for investigation of drug interactions. Both times, following drug administration, blood samples were collected at predetermined time intervals from the jugular vein of each animal and analyzed for INH by spectrophotometric analysis. PK parameters were calculated using two compartment open model. When used with paracetamol, the value of biological half life [t1/2beta] of INH was significantly decreased [p<0.05] from 2.391 +/- 0.216 to 2.17 +/- 3.46 hours. The value for apparent volume of distribution [Vd] was also significantly decreased [p<0.05] from 0.905 +/- 0.327 to 0.786 +/- 0.161 L/kg and total body clearance [CL] was increased insignificantly [p>0.05] from 3.59 +/- 2.03 to 4.04 +/- 2.61 mL/min/kg. Based on these results, it was concluded that dose of isoniazid should be increased when concomitantly used with paracetamol

Biodisposition of isoniazid after oral administration in teddy goats

Objective: to investigate the bio disposition of isoniazid in Teddy goats

Design: Experimental study

Material and methods: bio disposition of isoniazid [INH] was investigated in eight Teddy goats after single oral administration at the rate of 10 mg/Kg body weight. Blood samples were collected from each animal at pre-determined time intervals after drug administration. Plasma was isolated after centrifugation and analyzed for INH using spectrophotometer

Results: concentration versus time profile of each animal was used to determine the bio disposition of INH. Data was best described by two compartment open pharmacokinetic [PK] model and various PK parameters were calculated which were significantly different from the values in the literature

Conclusions: based on the results of this study it was concluded that disposition studies of imported antimicrobial drugs should always be conducted under indigenous conditions to rationalize their dosage regimen for local animal species